SELECTED PUBLICATIONS
Journals
  • M. J. Alcaraz, A.Habib, M. Lebret, C. Créminon, S. Lèvy-Toledano, J. Maclouf
    "Enhanced expression of heme oxygenase-1 by nitric oxide and antiinflammatory drugs in NIH 3T3 fibroblasts"
    Br.J.Pharmacol. 130(2000) 57-64.
  • F. Herencia, M. L. Ferrándiz, A. Ubeda, I. Guillén, José N. Domínguez, Jaime E. Charris, Gricela M.
    "4-Dimethylamino-3’,4’-dimethoxychalcone downregulates iNOS expression and exerts anti-inflammatory effects"
    Free Radic.Biol. Med. 30(2001) 43-50.
  • P. Molina, E. Aller, A. Lorenzo, P. Lopez-Cremades, I. Rioja, A. Ubeda, M.C. Terencio, M. J. Alcaraz
    "Solid-phase synthesis and inhibitory effects of some pyrido[1,2-c]pyrimidine derivatives on leukocyte functions and experimental inflammation"
    J. Med. Chem. 44(2001) 1011-1014.
  • A.M. Vicente, M. I. Guillén, M.J. Alcaraz
    "Modulation of zymosan-induced haem-oxygenase-1 expression by nitric oxide and leukotrienes in zymosan-activated macrophages"
    Br. J. Pharmacol. 133(2001) 920-926.
  • M. J. Alcaraz, A.Habib, M. Lebret, A. Vicente, C. Créminon, S. Lèvy-Toledano, J. Maclouf
    "Heme oxygenase-1 induction by nitric oxide in RAW 264.7 macrophages is upregulated by a cyclo-oxygenase-2 inhibitor"
    Biochim. Biophys. Acta 1526(2001) 13-16.
  • P. Molina, A. Tárraga, A. Gonzalez-Tejero, I. Rioja, A. Ubeda, M.C. Terencio, M. J. Alcaraz
    "nhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives"
    J.Nat. Prod. 64(2001) 1297-1300.
  • L.F. Ospina , J. Calle, L. Arteaga, R. Pinzón, M.J. Alcaraz, M. Payá
    "Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone"
    Planta Med. 67(2001) 91-95.
  • I. Rioja, M.C. Terencio, A. Ubeda, R. Riguera, J.M. Quintela, M.J. Alcaraz
    "A new ditriazine inhibitor of NF-κB modulates chronic inflammation and angiogenesis"
    Naunyn Schmiedeberg's Arch. Pharmacol. 365(2002) 357-364.
  • M. J. Alcaraz, I. Guillen
    "The nitric oxide-related therapeutic phenomenon: A challenging task"
    Current Pharmaceut. Des. 8(2002) 215-31.
  • I. Rioja, M.C. Terencio, A. Ubeda, P. Molina, A. Tárraga, A. Gonzalez-Tejero, M. J. Alcaraz
    "A pyrroloquinazoline derivative with anti-inflammatory and analgesic activity by dual inhibition of cyclo-oxygenase-2 and 5-lipoxygenase"
    Eur. J. Pharmacol. 434(2002) 177-185.
  • L. Lucas, M. Alves, E. Del Olmo, A. San Feliciano, M. Payá
    "LAAE-14, a new in vitro inhibitor of intracellular calcium mobilization, modulates acute and chronic inflammation"
    Biochem Pharmacol. 65(2003) 1539-49.
  • L. Lucas, C. Giannini, M.V. D’Auria, M. Payá
    "Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes"
    J. Pharmacol. Exp. Ther. 304(2003) 1172-1180.
  • M.J. Alcaraz, P. Fernández, M. I. Guillén
    "Anti-inflammatory actions of the heme oxygenase-1 pathway"
    Current Pharmaceut. Des. 9(2003) 2541-2551.
  • I. Posadas, .M. C. Terencio, A. Randazzo, L. Gomez-Paloma, M. Payá. M. J. Alcaraz
    "Inhibition of the nuclear factor-κB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M"
    Biochem. Pharmacol. 65(2003) 887-895.
  • P. Fernández, M. I. Guillén, A. Ubeda, P. López-Cremades, E. Aller, A. Lorenzo, P. Molina, M.J. Alcaraz
    "A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression"
    Naunyn-Schmiedeberg’s Arch. Pharmacol. 368(2003) 26-32.
  • I. Posadas, .S. De Rosa, M. C. Terencio, M. Payá. M. J. Alcaraz
    "Cacospongionolide B suppresses the expression of inflammatory enzymes and tumour necrosis factor-α by inhibiting nuclear factor-κB activation"
    Br. J. Pharmacol. 138(2003) 1571-1579.
  • A.M. Vicente, M. I. Guillén, M.J. Alcaraz
    "Heme oxygenase-1 induction and regulation in unstimulated mouse peritoneal macrophages"
    Biochem. Pharmacol. 65(2003) 905-909.
  • A.M. Vicente, M. I. Guillén, M.J. Alcaraz
    "Participation of heme oxygenase-1 in a model of acute inflammation"
    Exp. Biol. Med. 228(2003) 514-516.
  • Quintela JM, Peinador C, Gonzalez L, Devesa I, Ferrandiz ML, Alcaraz MJ, Riguera R.
    "6-Dimethylamino 1H-Pyrazolo[3,4-d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells"
    Bioorg. Med. Chem. 11(2003) 863-868.
  • P. Fernández, M. I. Guillén, F. Gomar, M.J. Alcaraz
    "Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes"
    Biochem. Pharmacol. 66(2003) 2049-2052.
  • A.M. Vicente, M. I. Guillén, A. Habib, M.J. Alcaraz
    "Beneficial effects of heme oxygenase-1 upregulation in the development of experimental inflammation"
    J. Pharmacol. Exp. Ther. 307(2003) 1030-1037.
  • A. Piris, W. Yong-Zheng, M. Paya, C. Delclaux, L. Touqui, P. Goossens
    "High bactericidal efficiency of Type IIA phospholipase A2 against Bacillus anthracis and inhibition of its secretion by the lethal toxin"
    J. Immunol. 127(2004) 521-30.
  • P. Fernández, M. I. Guillén, F. Gomar, E. Aller, P. Molina, M. J. Alcaraz
    "A novel cyclo-oxygenase-2 inhibitor modulates catabolic and antiinflammatory mediators in ostearthritis"
    Biochem. Pharmacol. 68(2004) 417-421.
  • M. J. Alcaraz, A.M Vicente, A. Araico, J.N. Domiguez, M.C. Terencio, M.L. Ferrándiz
    "Role of nuclear factor-κB and heme oxygenase-1 in the mechanism of action of an anti-inflammatory chalcone derivative in RAW 264.7 macrophages"
    Br. J. Pharmacol. 142(2004) 1191-1199.
  • I. Devesa, M.J. Alcaraz, R. Riguera, M.L. Ferrandiz
    "A new pyrazolo pyrimidine derivative inhibitor of cyclooxygenase-2 with anti-angiogenic activity"
    Eur. J. Pharmacol. 488(2004) 225-30.
  • J. Busserolles, M. Paya, M.V. D'Auria, L. Gomez-Paloma, M.J. Alcaraz
    "Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M"
    Biochem. Pharmacol. 69(2005) 1433-1440.
  • I. Devesa, M.L. Ferrandiz, M.C. Terencio, L.A.B. Joostens, W. B. van den Berg, M.J. Alcaraz
    "Modulation of heme oxygenase-1 influences the progression of murine collagen-induced arthritis"
    Arthritis & Rheum. 52(2005) 3230-3238.
  • I. Devesa, M.L. Ferrandiz,I. Guillén, J.M. Cerdá, M.J. Alcaraz
    "Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis"
    Lab. Invest. 85(2005) 34-44.
  • J. Busserolles, J. Megías, M.C. Terencio, M.J. Alcaraz
    "Heme oxygenase inhibits apoptosis in caco-2 cells via activation of Akt pathway"
    Int. J. Biochem. Cell Biol. 38(2006) 1510-1517.
  • A. Araico, M.C. Terencio, M.J. Alcaraz, J. N. Dominguez, C. Leon, M.L. Ferrandiz
    "Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase"
    Life Sci. 79(2006) 2911-2918.
  • Guillen,M.I., Megias,J., Gomar,F., Alcaraz,M.J.
    "The CO-Releasing Molecule Tricarbonyldichlororuthenium(II) dimer Exerts Protective Effects on Osteoarthritic Cartilage Metabolism"
    Arthritis & Rheum. 54(2006) S73.
  • M L Ferrándiz, N Maicas, I Garcia-Arnandis, M C Terencio, R Motterlini, I Devesa, L A B Joosten, W B van den Berg, M J Alcaraz
    "Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis"
    Ann. Rheum. Dis. 6(2007) E-pub ahead of print.
  • A. Araico, M.C. Terencio, M.J. Alcaraz, J. N. Dominguez, C. Leon, M.L. Ferrandiz
    ""Evaluation of the anti-inflammatory and analgesic activity of Me-UCH9, a dual cyclooxygenase-2/5-lipoxygenase inhibitor"
    Life Sci. 80(2007) 2108-2117.
  • J. Megías, J. Busserolles, M.J. Alcaraz
    "The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in caco-2 cells"
    Br. J. Pharmacol. 150(2007) 977-986.
  • M.I. Guillén, J. Megías, F. Gomar M.J. Alcaraz
    "Heme oxygenase-1 regulates catabolic and anabolic processes in osteoarthritic chondrocytes"
    J. Pathol. 214(2008) 515-522.
  • J. Megías, M.I. Guillén, A. Bru, F. Gomar, M.J. Alcaraz
    "The CO-releasing molecule CORM-2 protects human osteoarthritic chondrocytes and cartilage from the catabolic actions of interleukin-1"
    J. Pharmacol. Exp. Ther. 325(2008) 56-61.
  • M.I. Guillén, J. Megías, V. Clérigues, F. Gomar, M.J. Alcaraz
    "The CO-releasing molecule CORM-2 is a novel regulator of the inflammatory process in osteoarthritic chondrocytes"
    Rheumatology 0(2008) E-pub ahead of print.
Books
  • M.J. Alcaraz, J.B. Calixto, R. Delgado, Editores.
    Técnicas in vitro para el estudio de fármacos antiinflamatorios
    ISBN: 84-607-4952-5
    Pags: 1-198
    CYTED, Valencia, 2002
  • M.J. Alcaraz, J.C. T. Carvalho
    Flavonoides como agentes anti-inflamatorios, Fitoterápicos anti-inflamatórios.
    ISBN: 85-8665-308-X
    Pags: 79-100
    Tecmedd, Sao Paulo, Brasil, 2004
  • M.J. Alcaraz, M.L. Ferrándiz, M. Payá
    HISTAMINA Y ANTIHISTAMÍNICOS. OTROS MEDIADORES INFLAMATORIOS: BRADICININAS, PAF y NO.Velázquez. Farmacología General y Clínica
    ISBN: 84-7903-722-9
    Pags: 487-500
    17ed, , 2004